Explore our top-tier standardized botanical extracts engineered under rigorous cGMP protocols for pharmaceutical, nutraceutical, and functional food applications.
An authoritative evaluation of supply chain evolution, bioflavonoid market growth, and technical specifications for industrial buyers.
The global Rutin market is projected to expand at a CAGR of 6.8% through 2032. Growth is fueled by skyrocketing global demand for botanical vascular health solutions, natural antioxidants in anti-aging cosmetic formulations, and active pharmaceutical ingredients (APIs) targeting capillary fragility and venous insufficiency.
Enterprise B2B buyers are pivoting from raw botanical powders to standardized HPLC ≥98% pure Rutin and water-soluble bio-derivatives to meet strict pharmacopeial compliance across North America, Europe, and Asia-Pacific.
Native Rutin (Rutoside) suffers from low aqueous solubility (approx. 0.125 g/L at room temperature), limiting its formulation versatility. The industry is rapidly adopting Enzymatically Modified Rutin (EMR) / Alpha-Glycosyl Rutin (AGR).
Through transglycosylation technology, EMR achieves up to 12,000x greater water solubility while preserving core antioxidant, radical scavenging, and photoprotective properties, opening groundbreaking avenues in clear functional beverages and serum cosmetics.
Global pharma regulatory bodies (USP, EP, DAB, CP) are enforcing stringent residue limits. Wholesale buyers must navigate tight thresholds for residual solvents (Ethanol, Methanol), heavy metals (Pb, As, Cd, Hg < 10ppm total), and Ethylene Oxide (ETO) sterilants.
Factory audits now center on full batch traceability from raw Sophora japonica flower bud harvesting to final crystallization and clean-room packaging.
Comprehensive chemical parameter benchmark for pharmaceutical and nutraceutical grade wholesale Rutin bulk powder.
| Parameter / Specification | Pharma Grade (EP / USP / CP) | Dietary / Food Grade (NF11) | Enzymatically Modified (EMR) |
|---|---|---|---|
| Botanical Source | Sophora japonica L. (Flos Immaturus) | Fagopyrum esculentum / Sophora | Bio-transformed Enzymatic Catalysis |
| CAS Registry Number | 153-18-4 | 153-18-4 | 130603-71-3 / Modified |
| Molecular Formula & Weight | C27H30O16 • 610.52 g/mol | C27H30O16 • 610.52 g/mol | Variable Glycosylated Structure |
| Assay Standard (HPLC) | 98.0% – 102.0% | ≥ 95.0% (UV / HPLC) | ≥ 80.0% Isoquercitrin / Glucosides |
| Appearance | Yellow to Greenish-Yellow Powder | Light Yellow Fine Powder | Yellowish Water-Soluble Powder |
| Loss on Drying | ≤ 8.5% (Dab 10 / EP Standard) | ≤ 10.0% | ≤ 5.0% |
| Heavy Metals (ICP-MS) | Pb < 1ppm, As < 1ppm, Cd < 0.5ppm, Hg < 0.1ppm | Total Heavy Metals < 10ppm | Total Heavy Metals < 10ppm |
| Solvent Residues | Meets ICH Q3C Requirements (Ethanol-only extraction) | Complies with FDA Guidelines | Zero Toxic Solvent Residues |
| Microbiology Controls | Total Plate Count < 1,000 cfu/g; Salmonella/E.Coli Negative | Total Plate Count < 1,000 cfu/g; Yeasts & Molds < 100 cfu/g | USP Microbe Cleanliness Standard |
At Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB), our industrial manufacturing process abandons harsh synthetic solvents in favor of dynamic counter-current hydro-ethanolic extraction, combined with multi-stage membrane filtration and low-temperature recrystallization. This proprietary tech protects the delicate glycoside bond of Rutin (Quercetin-3-O-rutinoside), ensuring maximum bioactivity, superior crystal purity, and absolute zero ethylene oxide contamination.
Tailored high-purity botanical raw material engineering across pharmaceutical, nutraceutical, cosmeceutical, and functional beverage industries.
Rutin is widely prescribed as a bioflavonoid vascular protectant. It strengthens capillaries, reduces vascular permeability, and treats chronic venous insufficiency (CVI), hemorrhoids, and hemorrhagic retinopathy.
TRB supplies micronized pharmaceutical grade Rutin powder (Mesh 80 to Mesh 200) engineered for rapid dissolution in oral solid dosage forms (tablets, hard capsules) and complex multi-vitamin capillary fortification complexes.
As a potent singlet-oxygen quencher and lipid peroxidation inhibitor, Rutin prevents collagen breakdown caused by UVA/UVB exposure and oxidative stress. It reduces skin redness, capillary telangiectasia, and hyperpigmentation.
Our specialized liposomal-encapsulated Rutin and water-soluble Alpha-Glycosyl Rutin allow seamless incorporation into anti-aging serums, high-SPF sunscreens, and under-eye cream formulations without yellow staining or precipitation.
Rutin serves as a natural food preservative, inhibiting oxidation in edible oils, meat products, and functional food emulsions. It synergizes with Ascorbic Acid (Vitamin C) to regenerate antioxidants in real-time.
TRB’s customized water-dispersible Rutin complexes provide beverage manufacturers with a crystal-clear, sediment-free bioflavonoid fortifier for wellness shots, electrolyte drinks, and anti-inflammatory tonic lines.
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is China’s leading technology-driven manufacturer and exporter of standardized herbal extracts and bioflavonoid derivatives for over 20 years.
TRB operates three state-of-the-art production facilities: a specialized herbal extract extraction plant, a bee products refining facility, and an animal-derived biochemical isolation center. Our infrastructure satisfies international cGMP conditions, equipped with HPLC-DAD, LC-MS/MS, GC-MS, and ICP-MS testing hardware to guarantee full batch integrity.
Our dedication to plant science innovation earned TRB the prestigious 2026 Global Biotechnology and Life Sciences Award — ''Best Global Herbal Extract Provider 2026''.
Exporting to more than 60 countries across North America, the European Union, South America, and Southeast Asia, TRB delivers natural purity for all humanity.
Pioneering next-generation green extraction chemistry, synthetic biology options, and carbon-neutral bioflavonoid refinement.
To completely eliminate organic solvents, TRB’s R&D team is scaling Subcritical Water Extraction (SWE) technology for Rutin recovery. By tuning water dielectric constants under elevated temperature and pressure, SWE selectively extracts polyphenol glycosides with 99% purity while slashing carbon emission metrics by 45%.
Through collaborative biophysics research, TRB is engineering self-assembling lipid nanoparticles (LNPs) and cyclodextrin-inclusion complexes for wholesale Rutin powders. This enhances oral bioavailability by over 400%, protecting the compound against gastrointestinal enzymatic degradation.
Our Sophora japonica agricultural bases adhere to strict Good Agricultural and Collection Practices (GACP). Every batch of raw flower buds is tagged with blockchain-enabled geographical tracking, guaranteeing fair-trade grower practices and zero exposure to prohibited synthetic pesticides.
In-depth technical and commercial answers designed for raw material procurement managers, quality assurance leads, and formulation scientists.
Chemically, Rutin (Quercetin-3-O-rutinoside, C27H30O16) extracted from both botanical sources yields the identical active bioflavonoid molecule. However, Sophora japonica (Sophora flower bud) yields significantly higher raw purity (up to 15-20% native yield in unexpanded flower buds vs. 2-3% in Tartary Buckwheat). Sophora-derived Rutin allows a cleaner industrial purification process with far fewer complex carbohydrate impurities, making it the preferred choice for HPLC ≥98% pharmaceutical standards.
Native Rutin has a low aqueous solubility (~0.125 g/L). TRB offers two technical solutions: (1) Enzymatically Modified Rutin (EMR / Alpha-Glycosyl Rutin), produced via glucosyltransferase enzymatic conversion to attach glucose units to the flavonoid backbone, achieving complete water solubility (>100g/L) with crystal-clear clarity; and (2) Micronized / Cyclodextrin Inclusion Complexes tailored for high dispersion in functional beverage premixes.
TRB utilizes High-Performance Liquid Chromatography paired with Diode Array Detection (HPLC-DAD) according to European Pharmacopoeia (EP 10.0) and United States Pharmacopeia (USP 43) monographs. UV-Vis spectroscopy can overestimate Rutin purity by counting closely related flavonoids like Quercetin or Isoquercitrin. Our HPLC certification specifically isolates and quantifies pure Rutin trihydrate to guarantee strict compliance between 98.0% and 102.0%.
TRB enforces a strict non-toxic extraction protocol using only food-grade ethanol and purified water. Toxic Class 1 solvents (such as Benzene or 1,2-Dichloroethane) and Class 2 solvents (such as Methanol or Chloroform) are completely prohibited in our production zones. Residual ethanol levels are kept well below 3,000 ppm (ICH Q3C guidelines), and full Gas Chromatography (GC-FID/MS) testing reports accompany every batch dispatch.
Yes. Standard unground Rutin powder ranges around 60-80 mesh. TRB provides specialized physical processing including ultra-fine air-jet milling to achieve 100 mesh, 200 mesh, or micronized sub-10 micron powders. We also offer direct-compressible (DC grade) granulated Rutin with optimized bulk density and flowability for high-speed tablet pressing machines.
Our standard commercial MOQ starts at 25 kg (packaged in double food-grade polyethylene lined fiber drums). For evaluation and formulation trial stages, sample quantities (100g to 1 kg) are available upon request. Standard factory lead time is 3 to 7 working days post-order confirmation, supported by our global logistics hubs for sea, air, and express freight delivery.
Europe maintains strict regulatory frameworks (Regulation EC No 396/2005) regarding agricultural pesticide residues and zero tolerance for Ethylene Oxide (ETO). TRB utilizes advanced steam decontamination and heat sterilization technologies instead of ETO gas. Third-party testing validation (Eurofins / SGS) screen for 500+ pesticide residue parameters, ensuring full compliance for EU entry.
Every shipment includes a comprehensive Technical Dossier: Certificate of Analysis (CoA), Safety Data Sheet (SDS/MSDS), Detailed Manufacturing Flow Chart, Stability Data Report, BSE/TSE-Free Statement, Non-GMO Certification, Allergen Statement, and ETO-Free Declaration. DMF documentation support is also accessible for pharmaceutical partners.
Standard shelf-life is 24 to 36 months when stored unopened in original packaging. Rutin should be stored in a cool, dry, dark environment below 25°C and kept away from direct sunlight, strong light sources, and moisture. Proper sealing avoids ambient moisture absorption which could affect loss-on-drying specs.
Yes. Beyond raw bioflavonoid supply, TRB’s state-of-the-art solid dosage facility manufactures OEM/ODM custom blends, hard capsules, softgels, tablet pressings, and sachet stick-packs. We offer synergistic co-formulations combining Rutin with Vitamin C, Hesperedin, Troxerutin, Quercetin, or Ginkgo Biloba Leaf Extract tailored to your target market branding.
Discover TRB’s expanded portfolio of high-purity natural extracts, functional fruit powders, and specialized active ingredients.
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