Explore our top-selling specialized natural compounds, standard extracts, and premium wellness ingredients engineered for demanding B2B markets.
Fisetin (3,7,3',4'-tetrahydroxyflavone) is an organic flavonoid compound that has gained significant attention in modern clinical biochemistry and preventative nutrition. Classified as a highly selective senolytic agent, Fisetin target-clears senescent cells—frequently referred to as "zombie cells"—without harming surrounding healthy tissues.
Unlike standard dietary antioxidants, Fisetin exhibits superior pathway modulation. It operates via the inhibition of the mTOR path, upregulation of SIRT1 expression, and down-regulation of NF-kB pathways. As scientific publications on cellular homeostasis continue to rise, international demand for premium, industrial-grade bulk Fisetin has reached record heights, making raw material validation a critical priority for premium supplement formulators.
For more than 20 years, Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) has been a leading manufacturer and exporter of standard herbal extracts, amino acids, and biochemical derivatives. We run a comprehensive system that bridges academic research, plant genetics, precision manufacturing, and international logistics.
We operate three specialized plants dedicated to botanical extractions, animal derivative processing, and high-purity bee products. Our modern manufacturing facility is backed by a full suite of global industry credentials including GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER certifications.
We are proud to share that TRB's focus on research and quality has earned us the prestigious 2026 Global Biotechnology and Life Sciences Award—recognized internationally as the "Best Global Herbal Extract Provider 2026."
Our dedicated facilities utilize clean-room architectures and advanced separation technologies to ensure high purity and consistency across every batch.
Equipped with countercurrent extraction units and dynamic membrane separation systems. Capable of handling over 5,000 metric tons of raw botanical input annually under strict GMP guidelines.
Specifically isolated facility to process animal-source biomolecules such as high-purity deoxycholic acids, preventing cross-contamination with botanical lines.
Dedicated research and synthesis reactors focused on brain health, cellular longevity, and specialized cognitive compounds like Nefiracetam and high-yield Fisetin.
We serve as a strategic supplier to key international markets, offering tailored supply-chain models for global brands.
Full support for US FDA, European Food Safety Authority (EFSA), and TGA registration. Standardized EDMF, COA, MSDS, and third-party lab verification reports.
We offer custom particle milling including micronization down to D50 < 10 micrometers, helping to improve oral bioavailability and absorption in end-product formulations.
We maintain strategic stockpiles of raw Cotinus coggygria branches and raw materials, cushioning our clients from seasonal price swings and supply shortages.
Available in food-grade 1kg aluminum foil bags for pilot batches, up to 25kg double-PE lined fiber drums designed for commercial production lines.
A comparative look at our processing routes for commercial Fisetin production.
Our standard botanical route extracts active flavonoids from the wood and branches of Cotinus coggygria. This process utilizes ethanol and water-based countercurrent systems, avoiding toxic halogenated solvents.
Following crude extraction, the liquid undergoes resin chromatography to isolate target flavonoids, followed by recrystallization. The result is a premium botanical Fisetin (>98% pure HPLC) favored by clean-label brands.
For industrial applications requiring massive quantities and stable pricing, TRB's biotechnology lab is pioneering enzymatic pathways that convert abundant plant polyphenols directly into bio-identical Fisetin, reducing the carbon footprint of traditional synthesis.
We test every raw material batch at our on-site quality control center before dispatch. Using HPLC, ICP-MS, and GC-MS equipment, our laboratory checks every batch for active assay concentration, heavy metal levels (Arsenic, Lead, Cadmium, Mercury), solvent residues, and microbiological activity.
To better support international clients, we coordinate closely with customs brokers and maintain flexible logistics options to help navigate local regulatory guidelines in North America, Europe, and Asia-Pacific regions.
Key information for procurement officers, formulation scientists, and regulatory managers looking to source bulk Fisetin.
Our standard wholesale Fisetin is guaranteed at ≥98% purity, verified via High-Performance Liquid Chromatography (HPLC). Each shipment includes a Certificate of Analysis (COA) along with the raw HPLC chromatogram profile for validation.
We use ethanol and water as the primary extraction solvents. We do not use class-1 toxic organic solvents. Our final powder is dried under vacuum settings, keeping ethanol residue well below USP and EP limits (typically < 1000 ppm).
Our standard commercial MOQ is 25kg (packaged in one drum). However, we support pilot formulations by offering smaller test samples (e.g., 100g to 1kg) for initial R&D and analytical validation.
We offer both options based on client requirements. Our standard natural Fisetin is extracted from the wood of Cotinus coggygria. We also supply synthetic options for formulations requiring specific pricing structures.
Bulk Fisetin powder should be stored in original airtight containers, shielded from direct light, heat, and moisture. Under these conditions, the ingredient has a confirmed shelf life of 24 months from the manufacturing date.
Premium wholesale fruit powders, functional extracts, and specialized dietary ingredients.
Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
86-25-52863298
86-13770771528
Fax: 86-25-52867040
