Explore our core certified ingredient catalog manufactured at scale for Global Brands
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) stands as a prominent China-based pioneer and exporter of standardized herbal extracts and their natural derivatives for more than 20 years. As the industry consolidates towards strict purity and scientifically-validated ingredients, we deliver robust solutions bridging clinical efficacy with volume consistency.
For decades, TRB has specialized in marrying research and development with scalable production and international sales. In recognition of our advancements, quality management systems, and service excellence within the botanical sector, we have been awarded the prestigious 2026 "Global Biotechnology and Life Sciences Award" - "Best Global Herbal Extract Provider 2026".
Our comprehensive portfolio ranges from active flavones such as Luteolin Powder, to premium Sweeteners, Nootropics, Fruit & Vegetable juice powders, Essential oils, and Bee Products, catering to global pharmaceutical, nutraceutical, and cosmaceutical industries.
Our operational capacity spans three independent, specialized factories: a dedicated herbal extract facility, a specialized bee product processing center, and an advanced animal extract facility. Under strict process control, we maintain a comprehensive suite of internationally recognized quality management certifications, including GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER.
Focusing on the high-barrier market of Nootropics and cellular lifespan modulators, TRB invests heavily in research concerning Brain Health Herbal Extracts, Anti-Aging Botanical Fractions, and Longevity formulations, which consistently yield superior market feedback and clinical validations.
How modern extraction science is resolving solubility limitations to unlock cellular-level performance
Traditional Luteolin extraction methods suffer from low yield and solvent contamination. TRB incorporates subcritical water extraction coupled with high-efficiency column chromatography to guarantee a native Luteolin concentration of up to 98% by HPLC. This green chemistry approach eliminates toxic residues, meeting strict European and North American pharmacopeia criteria.
Luteolin's hydrophobic nature presents challenges regarding intestinal absorption. TRB’s scientific roadmap focuses on micronized crystallization and liposomal encapsulation. By reducing crystal particle size to a sub-micron scale (d90 < 10μm) or complexes with lecithin (Phytosome technology), the gastrointestinal absorption rate is boosted multi-fold compared to standard powders.
Looking to the next decade, TRB is exploring microbial fermentation pathways to synthesize premium flavonoids. Using genetically optimized yeast hosts to yield Luteolin from sustainable carbon inputs, this hybrid production model will run alongside plant extraction pipelines, ensuring absolute price stability and scalability for enterprise buyers.
| Analytical Parameter | Standard Specification | TRB Premium Grade Spec | Testing Methodology |
|---|---|---|---|
| Assay (Luteolin content) | ≥ 95.0% | ≥ 98.5% (Dry basis) | HPLC-DAD (External Standard) |
| Physical Appearance | Light Yellow Powder | Fine Light Yellow Crystalline Powder | Visual Inspection |
| Loss on Drying | ≤ 5.0% | ≤ 2.0% | USP <731> (105°C, 3h) |
| Heavy Metals (as Pb) | ≤ 10.0 ppm | ≤ 5.0 ppm (Arsenic <1.0 ppm) | ICP-MS (USP <233>) |
| Residual Solvents | Meet USP <467> | Ethanol only <500 ppm (Methanol-free) | GC-Headspace |
| Pesticide Residues | Complies with USP | Undetectable (EC 396/2005 Compliant) | LC-MS/MS |
Targeted applications engineered for modern product pipelines and diverse consumer demographics
With the rapid expansion of the aging global populace, brain health remains a key vertical. Luteolin inhibits neuro-inflammation by modulating microglia activation and crossing the blood-brain barrier. We supply specialized micronized grades for capsule blends, softgels, and smart-beverage powders that target brain fog, focus enhancement, and long-term memory support.
Luteolin works as a natural senolytic, assisting the clearance of senescent cells and downregulating the Senescence-Associated Secretory Phenotype (SASP). Combined with co-factors like NMN, Resveratrol, or Quercetin, our Luteolin powder serves as a core active ingredient in advanced longevity formulations designed to support cellular health and mitochondrial efficiency.
For individuals suffering from environmental sensitivities and histamine imbalances, Luteolin acts as a potent mast cell stabilizer. By reducing the release of inflammatory cytokines, it supports respiratory and dermatological systems. Our allergen-free, non-GMO Luteolin is highly sought after by clean-label dietary supplement companies globally.
Mitigating regulatory, geopolitical, and output fluctuations through vertical integration and smart manufacturing practices.
Operating from our headquarters in Nanjing and across our three state-of-the-art production sites, TRB executes a raw-material vertical integration program. We control raw materials from geographical origins to protect against crop yield variations. Our extraction systems utilize automated, closed-loop PLC configurations, minimizing energy consumption and achieving higher yield ratios.
By shifting to Factory 4.0 methodology, we ensure consistent batch production, reducing variations in product quality. Consequently, our clients receive stable pricing and reliable lead times regardless of volatile global market changes.
Providing reliable validation data, technical dossiers, and regulatory alignment for pharmaceutical and dietary supplement brands.
International sourcing teams must carefully balance price considerations against potential regulatory compliance risks. A typical low-cost supplier might fail quality verification checks, leading to cargo rejections at customs due to heavy metals, ethylene oxide (EtO), or unauthorized solvents.
TRB operates a highly sophisticated analytical testing laboratory equipped with HPLC, GC-MS, and ICP-MS systems. For every delivery, we issue a comprehensive Certificate of Analysis (CoA) matching global pharmacopoeial standards. Additionally, we provide complete documentation packets, including allergen statements, BSE/TSE-free certificates, GMO declarations, and flowcharts.
We export to more than 60 countries and regions. This extensive experience enables us to understand the regional compliance requirements of the US FDA, European Food Safety Authority (EFSA), and Japan's PMDA.
Ensuring smooth logistics and clearance through localized support hubs and comprehensive paperwork
To simplify the importing process for our international partners, TRB offers Delivered Duty Paid (DDP) shipping arrangements to North America, Europe, and parts of Asia. Through our regional logistics partners, we handle import customs clearance, duty payments, and local transport, delivering ingredients directly to your warehouse.
We welcome virtual and in-person factory audits by qualified third-party regulatory bodies. We provide complete batch records, validation protocols, cleaning logs, and environmental monitoring data, ensuring full compliance with FSMA, cGMP, and local health authority regulations.
Different formulation types require specific powder performance characteristics. We provide customized solutions to adjust density, particle size distribution, and cold-water dispersibility. Whether you are manufacturing direct-compression tablets, hard-shell capsules, or instant drink mixes, we can customize the powder to fit your processing line.
Addressing essential technical, quality, and procurement questions for enterprise sourcing managers
A: TRB extracts raw Luteolin primarily from natural, high-yield plant sources, including Sophora japonica, peanut shells (Arachis hypogaea), and chamomile flowers. Our selection process ensures sustainable harvesting and maximizes starting concentration, yielding a consistent raw material for purification.
A: Each production run undergoes full testing in our certified analytical lab. We use Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to confirm heavy metal levels fall safely below USP/EP limits. Pesticide residues are systematically screened using LC-MS/MS, conforming to strict EU and US regulatory requirements.
A: Our production processes and facilities hold multiple international certifications, including GMP, ISO, HACCP, ORGANIC, FDA registration, HALAL, and KOSHER. These credentials ensure our products meet quality compliance standards for distribution across global markets.
A: Yes, we provide custom micronization services. Standard shipments typically feature an 80-mesh powder. However, we can process Luteolin up to 200 mesh (or finer sub-micron distributions) to optimize solubility, blend uniformity, and processing performance in your manufacturing equipment.
A: Our standard MOQ for commercial Luteolin powder is 25kg (packaged in double-lined fiber drums). Sample quantities (1kg - 5kg) are available for R&D testing and pilot runs. Lead times generally range from 7 to 10 working days from payment confirmation to dispatch.
A: We minimize variations by managing raw material sourcing closely and utilizing automated PLC systems to control extraction parameters (temperature, pressure, duration, solvent ratio). Furthermore, each batch is blended uniformly and must pass HPLC assay validation before release.
Enhance your product formulations with our certified companion extracts
Unlock premium bioflavonoid solutions for your products. Contact TRB’s sales team to receive a current CoA, allergen statement, and custom volume quotation within 24 business hours.
Send Commercial Inquiry NowPioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
86-25-52863298
86-13770771528
Fax: 86-25-52867040
