Explore our premium range of highly standardized natural plant extracts engineered for nutraceutical, cosmetic, and functional food formulation compliance.
Scientific taxonomy, chemical compositions, and physiological properties driving natural ingredient demand.
Citrus Bioflavonoids constitute a diverse group of naturally occurring polyphenolic compounds located abundantly in the pericarp, flavedo, albedo, and segment walls of citrus fruits such as oranges (Citrus sinensis), lemons (Citrus limon), limes (Citrus aurantifolia), and grapefruits (Citrus paradisi). As therapeutic molecules, these plant secondary metabolites have garnered global clinical interest due to their unique physiological profiles. The primary molecules defining this category include flavanones like Hesperidin, Naringin, Neohesperidin, and Eriocitrin, alongside specialized flavones such as Polymethoxyflavones (PMFs) like Nobiletin and Tangeretin.
In B2B industrial formulation, Citrus Bioflavonoids are valued not just as antioxidants but as structural components in capillary-strengthening therapeutic protocols, immune modulator matrices, and natural anti-inflammatory cosmetics. Because these molecules demonstrate low bioavailability in their raw crystalline state, modern processing technology utilizes mechanical milling, chemical conversion (e.g., producing Hesperidin Methyl Chalcone), or molecular complexation to optimize their absorption profiles. As a result, global procurement managers seek standardized bioflavonoids to satisfy exact specification sheets across dietary supplements, functional beverages, and clinical therapeutics.
To implement an effective product development strategy, formulations must distinguish between the chemical structures and biological activities of specific flavonoids:
A look into the scientific processing steps required to extract, purify, and secure bioflavonoids at an industrial scale.
We source raw immature oranges (Citrus aurantium L.) and sweet oranges from validated agricultural cooperatives, ensuring optimal yield of hesperidin and naringin before maturity reduces the flavonoid concentration.
Applying temperature-controlled, food-grade ethanol-water mixtures. This preserves the structural integrity of the flavanones while removing unwanted sugars, pectin, and volatile organic oils.
For high-purity applications, macroporous resin columns separate distinct fractions (e.g., isolating 95% hesperidin or 98% naringin) from broader, complex bioflavonoid mixtures, achieving consistent standardization batch-over-batch.
By employing vacuum concentration and cold crystal growth, we prevent thermal degradation of heat-sensitive compounds, ensuring the physical crystalline shape is optimized for downstream tableting or blending.
Using selective ion exchange resins, we extract and reduce heavy metal ions, including Lead, Arsenic, Cadmium, and Mercury, to levels far below USP and European Pharmacopoeia regulatory thresholds.
Every industrial batch is subjected to High-Performance Liquid Chromatography (HPLC) to verify active ingredient values, while Gas Chromatography-Mass Spectrometry (GC-MS) checks for pesticide residues and solvent purity.
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) has been a leading manufacturer and exporter of herbal extracts and derivatives in China for more than 20 years.
As a technology-based enterprise, TRB integrates research and development, production, and international market sales. Our expansive product portfolio includes Herbal Extracts, Sweeteners, Nootropics, Vegetable & Fruit Juice Powders, Essential Oils, and Bee Products.
Driven by rapid development and dedicated service in the plant extract industry, we were honored with the 2026 "Global Biotechnology and Life Sciences Award" - "Best Global Herbal Extract Provider 2026".
TRB currently operates three dedicated factories: a herbal extract facility, a specialized bee product factory, and a facility for animal extract products. Our production processes conform to rigorous international standards, verified by GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER Certificates.
In recent years, TRB has focused on the research and development of nootropic and longevity molecules, such as Brain Health Herbal Extracts, Anti-Aging Botanical Fractions, and Longevity Compounds, yielding highly positive feedback from global clients.
TRB products are exported to more than 60 countries and regions, where we have established a strong reputation for reliability and quality. We remain committed to the research and development of pure natural plant extracts for human health.
How Citrus Bioflavonoids are utilized in large-scale commercial and consumer health ecosystems.
Used to formulate cardiovascular circulation supplements, varicose vein treatments (often combined with Diosmin), and immune-booster formulas utilizing the synergy between bioflavonoids and Vitamin C.
Employed in dry drink mixes, sports recovery juices, and functional tea preparations. Soluble chalcone derivatives provide bitterness-masking qualities and antioxidant preservation without altering product clarity.
High-purity Hesperidin and Eriocitrin are formulated into eye creams, skin-brightening serums, and environmental defense lotions to reduce redness, mitigate UV-induced oxidative stress, and soothe skin.
Neohesperidin and naringin derivatives act as natural performance enhancers and antioxidants in livestock diets. They help manage gut integrity and serve as natural flavor modifiers, supporting antibiotic-free farming initiatives.
We supply purified Hesperidin (up to 98% by HPLC) as a key raw material for semi-synthetic conversion into Diosmin and other critical cardioprotective APIs used globally in venous insufficiency therapy.
Due to their strong polyphenol activity, citrus bioflavonoid formulations are blended into natural preservation systems, inhibiting lipid oxidation and maintaining color stability in complex food emulsions.
A transparent look at our advanced cleanroom extraction areas, warehouse storage facilities, and analytical laboratory testing sites.
Direct technical advice from our laboratory directors to help clarify formulation, stability, and supply chain logistics.
Explore our complete range of specialized botanical ingredients designed for functional foods and nutraceutical formulations.
Request standard samples, certificate packets, and custom quotes. Our sales and engineering teams reply within 24 business hours.
Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
Office: 86-25-52863298
Mobile/WeChat: 86-13770771528
Fax: 86-25-52867040
