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Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is a leading technology-based manufacturing powerhouse in China, specializing in the research, development, and international scale export of high-potency herbal extracts and bioflavonoid derivatives for more than 20 years.
As a pioneer in natural molecule crystallization, TRB has dedicated decades to optimizing active compound isolation. By utilizing state-of-the-art supercritical carbon dioxide extraction and high-resolution chromatography, we supply industries globally with standard-setting ingredients, including our premium-grade Apigenin Powder.
Our rapid growth and uncompromised standard of service in the global plant extract industry were recognized with the prestigious 2026 Global Biotechnology and Life Sciences Award: "Best Global Herbal Extract Provider 2026".
A deep, data-driven analysis of global demand, extraction chemistry, pharmacology, and standard protocols for bulk apigenin sourcing.
Apigenin (4',5,7-Trihydroxyflavone) is a naturally occurring plant flavone that exhibits a broad spectrum of bioactivities. Found abundantly in chamomile flowers (Matricaria recutita), celery (Apium graveolens), and parsley, this yellow crystalline compound is highly recognized for its therapeutic potential in health optimization. Its physiological effects are primarily driven by its ability to cross the blood-brain barrier and bind to central receptors, as well as modulate crucial enzymatic cascades.
Pharmacologically, apigenin acts as a selective inhibitor of CD38, a glycoprotein that hydrolyzes NAD+ (Nicotinamide Adenine Dinucleotide) and its precursor NMN. By suppressing CD38 activity, apigenin effectively maintains and restores intracellular NAD+ pools, which are vital for sirtuin activation, mitochondrial biogenesis, and cellular DNA repair. Additionally, apigenin is widely recognized for its positive modulation of GABA-A receptors, leading to mild anxiolytic and sleep-inducing benefits without the cognitive impairment commonly associated with synthetic sedative drugs.
The global demand for high-purity Apigenin powder has experienced an exponential spike, fueled by the rapid expansion of the longevity, wellness, and functional beverage industries. Over the last five years, anti-aging science has evolved from passive supplementation to cellular repair targeting, placing CD38 inhibitors at the top of ingredient procurement lists for leading supplement brands in North America, Western Europe, and the Asia-Pacific region.
Moreover, the modern dietary supplement market is shifting away from synthetic molecules in favor of botanical alternatives. High-purity chamomile-derived apigenin powder serves as an optimal solution, offering a clean label profile that aligns with clean-ingredient demands. Sourcing managers are increasingly demanding verified 98% pure apigenin to guarantee formulation stability, eliminate batch-to-batch inconsistencies, and comply with strict national health regulations.
To maintain compliance across international regulatory agencies, TRB manufactures Apigenin powder to the highest purity standards. Our QA and testing protocols ensure that each batch is tested via HPLC-DAD (High-Performance Liquid Chromatography with Diode-Array Detection) to confirm purity and ensure the absence of residual solvents or agricultural toxins.
Our standard specification sheet for high-purity Apigenin 98% represents the benchmark for pharmaceutical and nutraceutical formulations globally.
| Parameters | Standard Specification |
|---|---|
| Assay (HPLC) | ≥ 98.0% Apigenin |
| Source | Chamomile (Matricaria recutita) |
| Appearance | Light yellow to pale green crystalline powder |
| Mesh Size | 100% through 80 Mesh |
| Loss on Drying | ≤ 2.0% |
| Heavy Metals (Pb, As, Cd) | ≤ 10 ppm (Total) |
| Residual Solvents | Ethanol Only (≤ 5000 ppm) |
One of the main challenges in formulating with raw apigenin powder is its low water solubility and corresponding poor oral bioavailability. To help our global partners overcome this limitation, TRB’s research division offers customized physical processing techniques. These advanced methods enhance dissolution profiles and overall bioavailability in the human GI tract:
TRB ensures seamless customs clearing and full regulatory compliance across international markets, protecting your brand from supply chain liabilities.
TRB's three manufacturing plants operate under strict GMP protocols. Our processes are fully audited by third-party international agencies, ensuring consistent compliance for your regular quality checks.
We maintain an extensive registry of internationally recognized quality certificates, including ISO, HACCP, ORGANIC, FDA facility registration, HALAL, and KOSHER, allowing for frictionless distribution worldwide.
Having exported to over 60 countries, our supply chain and logistics team handles customs documentation, heavy metal and pesticide residue compliance, and local import requirements.
Innovative crystallization techniques designed to minimize environmental impact while maximizing potency and safety.
TRB is committed to green extraction methods that avoid harsh petrochemical solvents. Our production process relies exclusively on food-grade ethanol and purified water. The raw chamomile undergoes a multi-stage solid-liquid extraction process, where parameters such as temperature, extraction time, and solvent ratio are carefully monitored by automated SCADA systems.
Following extraction, the solution is filtered and concentrated under vacuum conditions. Chromatography columns selectively capture the apigenin molecule, parting it from unwanted plant sugars and chlorophyll. The isolated apigenin is then crystallized in controlled conditions, resulting in high-purity yellow crystals that are dried, micronized under sterile conditions, and sealed in double-layer food-grade PE bags inside heavy-duty fiber drums.
Looking to the future, TRB’s biotechnology research division is exploring hybrid synthetic biology techniques to produce cost-effective, bio-identical apigenin. This method aims to lower carbon emissions and scale up production to meet the growing demand from global beverage and functional food brands.
Get answers to technical, regulatory, and logistics questions about sourcing Apigenin powder from China.
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Reach out to our sales engineering team today to request free product samples, receive pricing for bulk orders, or discuss custom formulation options.
Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
86-25-52863298 / 86-13770771528
86-25-52867040
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