Wholesale Naringin Dihydrochalcone Manufacturers & Factory

Premium Grade Neo-Sweetener & Bitter Blocker Solutions. Direct from China's Leading Phytochemical Synthesis Experts.

Understanding Naringin Dihydrochalcone (NDC)

Naringin Dihydrochalcone (Naringin DC / NDC) is a semi-synthetic sweetener and flavor modifier derived from naringin, a natural bitter flavonoid found abundantly in grapefruit and other citrus peels. Through a precise catalytic hydrogenation process, the bitter naringin is transformed into a highly potent sweetener that is approximately 300 to 500 times sweeter than sucrose at threshold concentrations.

Unlike traditional artificial sweeteners, Naringin Dihydrochalcone offers a clean, lingering sweetness profile characterized by a slight cooling effect and a slow onset. Its unique molecular structure allows it to act as an exceptional bitter blocker, masking the off-tastes of plant-based proteins, vitamins, and active pharmaceutical ingredients (APIs).

CAS Number 18916-17-1
Molecular Formula C27H34O14

Key Advantages of TRB's Naringin DC

  • High Sweetness Intensity: 300x-500x sweeter than sugar, reducing formulation volume and costs.
  • Flavor Modification: Excellent masking of metallic, bitter, and astringent notes.
  • Synergistic Effects: Works in harmony with Stevia, Mogrosides, and Neohesperidin DC.
  • Thermostability: Remains stable under high-temperature processing (pasteurization, UHT, baking).
  • Zero Glycemic Index: Safe for diabetic food formulations and weight management products.

Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB)

Your Trusted Global Partner for High-Quality Phytochemicals and Sweetener Solutions.

TRB Factory Facility 1 TRB Factory Facility 2 TRB Lab Testing TRB Production Line

20+ Years of Extraction & Synthesis Expertise

Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is a China-leading manufacturer and exporter of herbal extracts and their derivatives for more than 20 years. As a technology-based enterprise, we seamlessly integrate research and development, state-of-the-art production, and international sales.

Our comprehensive product portfolio includes Herbal extracts, Sweeteners, Nootropics, Vegetable & Fruit Juice powder, Essential oils, and Bee Products. Over the decades, TRB's rapid development and dedicated service have earned us the prestigious 2026 Global Biotechnology and Life Sciences Award: "Best Global Herbal Extract Provider 2026".

TRB currently operates three specialized factories: one dedicated to herbal extracts (including Naringin Dihydrochalcone synthesis), one for bee products, and another for animal-derived extracts. Our facilities are fully certified under global standards, including GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER.

GMP Certified ISO 9001:2015 HACCP FDA Registered HALAL & KOSHER Organic Certified
20+
Years Experience
3
Modern Factories
60+
Countries Exported
99%
Purity Grade (HPLC)

Macro-Industry Solutions & Global Market Status

How Naringin Dihydrochalcone is shaping the future of sugar reduction and clean-label formulations globally.

Sugar Reduction Initiatives

Governments worldwide are implementing sugar taxes and front-of-pack warning labels. Food and beverage manufacturers are under immense pressure to reformulate products. Naringin DC provides a cost-effective, high-intensity sweetening solution that allows brands to cut sugar content by up to 100% without sacrificing sensory appeal.

Bitter Masking in Pharma

Active Pharmaceutical Ingredients (APIs) and pediatric suspensions often carry intense bitterness. Traditional flavorings struggle to mask these notes. Naringin DC acts directly on the human taste receptors, blocking bitter signals and significantly improving patient compliance, particularly in liquid formulations and chewable tablets.

Clean Label & Natural Sourcing

Consumers are rejecting synthetic artificial sweeteners like Aspartame and Acesulfame-K. Derived from natural citrus flavonoids, Naringin Dihydrochalcone aligns perfectly with the clean-label movement. It is recognized as a safe, nature-identical flavoring substance across major global markets.

Precision Synthesis & Technical Route

At TRB, our manufacturing process for Naringin Dihydrochalcone is executed under strict GMP conditions to ensure maximum purity, stability, and safety. The synthesis route involves:

  1. Extraction: High-grade Naringin is extracted from the immature fruit of Citrus aurantium L. or grapefruit peel using eco-friendly aqueous-ethanol solvents.
  2. Alkaline Ring Opening: The chalcone intermediate is formed by treating naringin with a dilute alkaline solution under controlled temperatures.
  3. Catalytic Hydrogenation: The chalcone undergoes catalytic hydrogenation using high-efficiency noble metal catalysts (such as palladium on carbon) to saturate the double bond, yielding Naringin Dihydrochalcone.
  4. Purification & Crystallization: The crude NDC is purified via recrystallization, filtered, and dried in cleanrooms to achieve a final purity of ≥98% by HPLC.

Every batch undergoes rigorous quality control testing, including heavy metal analysis, pesticide residue screening, and microbiological assays, ensuring compliance with USP, EP, and FCC standards.

Technical Specifications

Appearance White to off-white crystalline powder
Assay (HPLC) ≥ 98.0%
Loss on Drying ≤ 12.0%
Heavy Metals ≤ 10 ppm
Lead (Pb) ≤ 1.0 ppm
Arsenic (As) ≤ 1.0 ppm
Total Plate Count ≤ 1000 cfu/g

Localized Application Scenarios

Tailored formulations for diverse industries to optimize taste profiles and reduce production costs.

Carbonated & Still Beverages

In low-calorie soft drinks, fruit juices, and iced teas, Naringin DC works synergistically with stevia to round out the sweet curve, eliminating the late-onset bitter aftertaste often associated with steviol glycosides.

Nutraceuticals & Protein Powders

Plant proteins (pea, soy, hemp) and collagen peptides carry inherent earthy and bitter notes. Adding trace amounts of Naringin DC (5-10 ppm) masks these off-flavors, allowing for cleaner, more palatable protein shakes.

Animal Feed Appetizers

In piglet and calf feeds, Naringin DC is widely used as a sweetening agent to improve feed palatability. It stimulates salivation and gastric juice secretion, promoting feed intake and accelerating animal growth rates.

Technical Roadmap & Future Outlook

TRB's commitment to sustainable production, green chemistry, and next-generation flavor modification.

01

Enzymatic Biotransformation (Green Synthesis)

We are actively transitioning our hydrogenation phase from traditional chemical catalysts to enzymatic biocatalysis. This reduces heavy metal waste and lowers the carbon footprint of our Naringin DC production by 35%.

02

Micro-Encapsulation Technology

To address solubility limitations in cold beverages, TRB is developing micro-encapsulated Naringin DC. This formulation ensures rapid dissolution and uniform sweetness dispersion in instant drink powders.

03

Synergistic Sweetener Blends

Our R&D team is launching pre-formulated sweetener systems combining Naringin DC, NHDC, and Monk Fruit extract. These plug-and-play blends offer a sugar-like taste profile with zero calories, simplifying formulation for food scientists.

Frequently Asked Questions

Get authoritative answers to technical, regulatory, and commercial inquiries about Naringin Dihydrochalcone.

What is the primary difference between Naringin DC and Neohesperidin DC (NHDC)?
While both are dihydrochalcone sweeteners derived from citrus flavonoids, NHDC is derived from neohesperidin and is roughly 1500-1800 times sweeter than sugar, with a strong licorice-like aftertaste. Naringin DC is derived from naringin, is 300-500 times sweeter than sugar, and has a milder, cleaner sweetness profile with less lingering aftertaste, making it easier to formulate in delicate flavor systems.
Is Naringin Dihydrochalcone approved for food use globally?
Yes, Naringin DC is approved as a flavoring substance and sweetener in many jurisdictions. It is listed in the European Union's register of flavouring substances (FL No. 16.024) and has FEMA GRAS status (FEMA No. 4390) in the United States, allowing its use as a flavor modifier. It is also approved in China under GB2760 standards.
How does Naringin DC perform under high-temperature processing?
Naringin DC exhibits excellent thermal stability. It can withstand temperatures up to 140°C without degrading or losing sweetness, making it highly suitable for pasteurization, UHT sterilization, and baking applications.
What is the typical dosage of Naringin DC in food and beverage formulations?
When used as a flavor enhancer or bitter blocker, the typical dosage ranges from 5 to 15 ppm (parts per million). When used as a primary sweetener, the dosage can range from 20 to 50 ppm, depending on the target sweetness level and the presence of other synergistic sweeteners.
What certifications does TRB hold for its manufacturing facilities?
TRB's factories are certified under GMP, ISO 9001, HACCP, HALAL, KOSHER, and Organic standards. We are also registered with the US FDA, ensuring full compliance for exports to North America, Europe, and Asia-Pacific regions.

Get in Touch with Our Technical Sales Team

Partner with China's leading manufacturer of Naringin Dihydrochalcone. Contact us today for technical documentation, free samples, and custom formulation support.

  • Visit Us: Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
  • Call Us: 86-25-52863298 / 86-13770771528
    Fax: 86-25-52867040
  • Email Us: [email protected] / [email protected]

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