Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is China's leading manufacturer and exporter of premium herbal extracts, functional food ingredients, and active derivatives for more than 20 years. As a pioneer in the global longevity and cognitive health sectors, TRB seamlessly integrates cutting-edge scientific research and development, modern manufacturing facilities, and international sales networks.
Our comprehensive portfolio includes Herbal Extracts, Sweeteners, Nootropics, Vegetable & Fruit Juice Powders, Essential Oils, and Bee Products. Our dedication to unmatched quality control and responsive service within the plant extraction and biochemical industries has earned us esteemed industry recognitions, including the prestigious 2026 "Global Biotechnology and Life Sciences Award" as the "Best Global Herbal Extract Provider 2026".
Currently, TRB operates three specialized production facilities: a dedicated herbal extract facility, a state-of-the-art bee products facility, and a modern biological animal extract facility. Each of our factories maintains complete regulatory certifications, ensuring every batch meets international standards for quality and traceabilty, including GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER certificates.
In recent years, TRB has focused its innovation pipelines on the research, development, and scaling of nootropic compounds, brain-boosting active compounds, and anti-aging precursors. Our high-purity Nicotinamide Riboside Chloride (NR-Cl) powder represents the zenith of this focus, providing nutritional brands globally with a reliable, highly bioavailable NAD+ precursor.
In the rapidly expanding cellular longevity market, Nicotinamide Riboside Chloride (NR-Cl) has established itself as one of the premier agents for increasing intracellular Nicotinamide Adenine Dinucleotide (NAD+) levels. As cells age, natural NAD+ concentrations diminish, contributing to mitochondrial dysfunction, decreased DNA repair capabilities, and metabolic decline. By supplementing with high-purity NR-Cl, researchers and consumers can effectively support cellular rejuvenation pathways.
Nicotinamide Riboside Chloride possesses unique transport pathways into the cell. Unlike larger nucleotide compounds, NR can directly traverse cellular membranes via equilibrative nucleoside transporters (ENTs). Once inside, it bypasses key rate-limiting enzymes of the salvage pathway, rapidly converting into NAD+. This pathway makes it highly sought-after in standard regulatory jurisdictions, such as the European Union and standard US dietary markets.
NAD+ is a critical coenzyme found in all living cells, vital for energy metabolism and maintaining genomic stability. It serves as an essential substrate for Sirtuins—often labeled the "longevity proteins"—and Poly (ADP-ribose) Polymerases (PARPs) which manage DNA damage response mechanisms. Elevating NAD+ levels through high-efficacy NR-Cl supplementation stimulates mitochondrial biogenesis, which helps delay age-related physiological decline.
Consumers seeking anti-aging support, cognitive enhancement (nootropics), metabolic optimization, and athletic performance recovery are driving global demand for NR-Cl. B2B supplement brands are formulating customized NR-Cl capsule lines, tablet options, functional drinks, and multi-ingredient metabolic stacks to serve these tech-savvy, wellness-oriented demographics.
As the world's primary hub for botanical extraction and pharmaceutical synthesis, China offers unparalleled supply chain resilience and cost efficiency. Sourcing NR-Cl powder directly from Nanjing Tong Rui Bio-Tech (TRB) guarantees high-level industrial integration, raw material optimization, and chemical engineering expertise.
Our large-scale chemical synthesis reactors and automated control lines significantly reduce production overhead, allowing us to pass price advantages directly to international buyers.
We utilize cutting-edge biological enzymatic reaction techniques and precision crystallization processes to ensure clean, consistent crystallization and minimize chemical solvent impurities.
From starting raw materials to final crystallization stages, every step is strictly monitored using state-of-the-art chromatography to ensure maximum batch safety and uniformity.
Strategically located near major shipping corridors in Nanjing, TRB guarantees efficient air, sea, and express logistics, offering rapid transit routes to major global hubs.
Every batch of Nicotinamide Riboside Chloride (NR-Cl) powder undergoes rigorous laboratory analysis to ensure high standards of safety, quality, and efficacy. Review our standard commercial release parameters below:
| Testing Parameter | Standard Specification Limits | Testing Method (Methodology) |
|---|---|---|
| Appearance | White to Off-White Crystalline Powder | Visual / Organoleptic Analysis |
| Assay (Purity) | ≥ 99.0% (Dry Basis) | High Performance Liquid Chromatography (HPLC) |
| Water Content | ≤ 2.0% | Karl Fischer Titration |
| Heavy Metals (Pb, As, Cd, Hg) | ≤ 10 ppm total (Individual elements ≤ 1 ppm) | ICP-MS (Inductively Coupled Plasma Mass Spectrometry) |
| Residual Solvents | Conforms to USP/ICH limits (Ethanol ≤ 5000ppm) | GC-MS (Gas Chromatography-Mass Spectrometry) |
| Total Aerobic Microbial Count | ≤ 1000 cfu/g | USP <61> Microbiological Examination |
| Yeast and Mold | ≤ 100 cfu/g | USP <61> Microbiological Examination |
| Escherichia Coli / Salmonella | Negative / Absent in 10g | USP <62> Pathogenic Screening |
Navigating the complex global regulatory landscapes for health ingredients requires deep compliance knowledge. TRB provides full-spectrum support for international markets, matching regulatory requirements with complete traceabilty documentation. Whether your market falls under EU Novel Food classifications, FDA New Dietary Ingredient (NDI) filings, or local chemical registrations, we provide the dossiers needed for swift clearance.
TRB supports your US distribution channels by providing complete specifications, raw material traceabilty flowcharts, and GMP certifications. Our testing data matches standard requirements, making the preparation of self-affirmed GRAS notifications or NDI submissions easier for your brand.
Nicotinamide Riboside is authorized as a Novel Food within the European Union under strict safety guidelines. TRB produces NR-Cl within ISO and GMP certified environments, providing the safety datasheets, allergen statements, and heavy metal testing profiles required to meet EFSA compliance.
Every market is unique. Our team offers custom particle size adjustments (micronization), specific density optimizations for capsules, and custom formulation solutions. We collaborate with you to deliver materials prepared specifically for your manufacturing line.
Nicotinamide Riboside Chloride is a versatile ingredient. Its stability and solubility allow it to be integrated into diverse formulation architectures across the health, wellness, and beauty sectors.
Ideal for single-entity capsules or multi-ingredient formulations paired with Resveratrol, Pterostilbene, or CoQ10. Highly stable in dry-powder capsules, tablets, and hard-shell formulations.
Exhibits excellent water solubility, enabling it to be formulated into dry-mix meal replacement powders, brain health shakes, and pre-workout focus drink formulations.
Utilized in cosmetic creams and serum formulations to support energy-dependent repair pathways in skin cells, improve barrier function, and target signs of aging.
Explore detailed answers to common inquiries regarding B2B sourcing, quality specifications, and applications for bulk NR-Cl powder.
Connect directly with our sales department and tech consultants for custom quotes, COA documents, and sample evaluations.
Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
86-25-52863298
86-13770771528
86-25-52867040
