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Luteolin (3',4',5,7-tetrahydroxyflavone) is a naturally occurring flavone found in a wide variety of plants, including fruits, vegetables, and medicinal herbs. In recent years, the global demand for Luteolin has surged exponentially, driven by its potent anti-inflammatory, antioxidant, neuroprotective, and anti-tumor properties. As global consumers increasingly shift toward preventative health and longevity supplements, Luteolin has emerged as a cornerstone ingredient in advanced nutraceutical formulations.
From an industrial perspective, Luteolin is primarily sourced from raw materials such as Sophora japonica extract, peanut shells, and various herbal plants. The commercialization of Luteolin requires highly sophisticated extraction and purification technologies to achieve the high purity levels (typically 98% HPLC) demanded by pharmaceutical and high-end dietary supplement brands. As a result, the supply chain is highly concentrated among specialized manufacturers capable of balancing yield, purity, and cost-efficiency.
Utilized as an active pharmaceutical ingredient (API) in research and formulation targeting chronic inflammatory diseases, metabolic syndromes, and neurodegenerative disorders.
Incorporated into brain health supplements, longevity formulas, and cellular defense products to inhibit microglial activation and support cognitive function.
Leveraged in premium skincare products for its ability to mitigate UV-induced oxidative stress, reduce skin inflammation, and inhibit melanogenesis.
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is a leading China-based manufacturer and exporter of premium herbal extracts and their derivatives, boasting over 20 years of industry experience. Established as a technology-driven enterprise, TRB seamlessly integrates scientific research and development, state-of-the-art production, and global sales distribution.
Our comprehensive product portfolio spans high-quality Herbal extracts, Natural Sweeteners, Nootropics, Vegetable & Fruit Juice powders, Essential oils, and Bee Products. Over the decades, TRB's unwavering commitment to quality and service has earned us prestigious recognition, including the 2026 Global Biotechnology and Life Sciences Award as the "Best Global Herbal Extract Provider 2026".
To meet the diverse demands of our international clientele, TRB operates three specialized manufacturing facilities: one dedicated to herbal extracts (including high-purity Luteolin), one for bee products, and another for animal-derived extracts. Our facilities are fully certified under international quality and safety standards, ensuring complete regulatory compliance across global markets:
In recent years, TRB has strategically focused on the R&D of Nootropics and Longevity compounds. Our Brain Health Herb Extracts, Anti-Aging Herb Extracts, and Longevity Herb Extracts have received exceptional feedback from clients in North America, Europe, and Asia-Pacific, establishing TRB as a premier supplier in the global anti-aging sector.
China is the global powerhouse for plant extraction, controlling over 70% of the global herbal extract supply chain. Sourcing Luteolin from a premier Chinese manufacturer like TRB offers significant strategic advantages for global brands:
China possesses vast agricultural resources for sourcing Luteolin-rich raw materials, particularly Sophora japonica and peanut shells. TRB maintains long-term contract farming agreements, ensuring a stable, traceable, and pesticide-controlled raw material supply. This vertical integration insulates our clients from raw material price volatility and supply shortages.
TRB utilizes proprietary multi-stage crystallization and chromatography technologies to isolate Luteolin. Unlike standard extraction methods that result in low purity or high solvent residues, our process yields Luteolin with a purity of up to 98% HPLC while keeping residual solvents (such as ethanol) well below USP and EP limits. Our state-of-the-art facilities are equipped with automated production lines that maximize yield and minimize human error.
By operating three large-scale manufacturing plants, TRB achieves significant economies of scale. We pass these cost savings directly to our partners, offering highly competitive wholesale pricing without compromising on quality. Furthermore, our location in Nanjing provides excellent logistics infrastructure, enabling rapid shipping via major air and sea ports.
Luteolin's versatile biological activities make it highly sought after across various regional markets, each focusing on distinct application scenarios:
In the United States and Canada, there is a booming demand for nootropics that support focus, memory, and brain longevity. Luteolin is frequently formulated alongside Palmitoylethanolamide (PEA) or Rutin to create synergistic blends that target neuroinflammation and support microglial health. TRB provides micronized Luteolin powder to enhance bioavailability in capsule and tablet formulations.
European consumers are highly focused on healthy aging and preventive medicine. Luteolin is recognized as a potent senolytic agent—a compound that selectively clears senescent cells. It is commonly combined with Quercetin, Fisetin, and Resveratrol in premium anti-aging supplements designed to promote cellular rejuvenation and cardiovascular health.
In the APAC region, particularly in Japan, South Korea, and China, Luteolin is widely used in respiratory health supplements due to its traditional use in soothing coughs and reducing lung inflammation. Additionally, the cosmetic industry utilizes high-purity Luteolin in topical formulations for its skin-soothing, anti-inflammatory, and anti-hyperpigmentation properties.
For global procurement managers, ensuring the quality, safety, and consistency of active ingredients is paramount. TRB adheres to rigorous quality assurance protocols to guarantee that every batch of Luteolin meets international standards:
Get authoritative answers to common technical and commercial questions about Luteolin sourcing.
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Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
Phone: 86-25-52863298
Mobile: 86-13770771528
Fax: 86-25-52867040