As global consumers shift toward wellness, active recovery, and clean-label functional ingredients, Dihydromyricetin (DHM)—derived predominantly from Ampelopsis grossedentata (commonly known as Vine Tea)—has emerged as a foundational molecule. Below we explore the raw science, biochemical pathways, and sourcing considerations that global buyers must prioritize.
Dihydromyricetin (CAS No. 27200-12-0), also known as ampelopsin, is a naturally occurring flavanonol. In recent years, extensive studies from clinical pharmacologists and neurologists have established its ability to mitigate liver stress, aid in alcohol metabolism, and exhibit profound neuroprotective properties. For global brands formulating hangover remedies, anti-aging solutions, and hepatoprotective capsules, sourcing DHM powder from verified, GMP-compliant factories in China is vital to ensuring maximum clinical efficacy and safety.
Historically, Vine Tea was consumed in Southern China as a regional remedy for inflammation, throat irritation, and liver recovery. Today, using state-of-the-art solid-liquid extraction (SLE), macroporous adsorption resin columns, and solvent recrystallization, Chinese manufacturers extract DHM at purity levels reaching up to 98%. This high concentration makes it highly adaptable for diverse manufacturing lines—from soft gelatin capsules and hard-shell tablets to water-dispersible powdered beverage blends.
| Specification Parameter | Standard Specification (98% DHM Powder) | Testing Methodology |
|---|---|---|
| Active Compound (Ampelopsin) | ≥ 98.0% (Dry Basis) | HPLC (High-Performance Liquid Chromatography) |
| Appearance | Off-white to white crystalline fine powder | Visual Inspection |
| Source Botanical | Ampelopsis grossedentata (Leaves) | TLC (Thin Layer Chromatography) Identification |
| Loss on Drying | ≤ 2.0% | Gravimetric analysis (105°C, 3 hours) |
| Heavy Metals (as Pb) | ≤ 10.0 ppm | ICP-MS (Inductively Coupled Plasma Mass Spec) |
| Residual Solvents | Ethanol only (≤ 5000 ppm), Methanol free | GC-MS (Gas Chromatography Mass Spec) |
Achieving high purity while maintaining environmental sustainability and cost efficiency is the hallmark of modern extraction plants. The manufacturing process of Dihydromyricetin involves a complex multi-stage separation process designed to preserve the molecular integrity of the flavanonol.
We harvest wild and cultivated Ampelopsis grossedentata leaves from specialized high-altitude agricultural zones in southern China. These leaves undergo strict quality audits for moisture levels, pesticide residuals, and initial flavonoid concentrations before entering the crushing mills.
Utilizing a clean water and food-grade ethanol countercurrent extraction system, the target compounds are gently isolated without the use of harsh organic solvents such as methanol or chlorinated hydrocarbons, meeting strict EU and FDA standards.
The extract passes through dynamic adsorption columns using food-grade resins, separating dihydromyricetin from other polyphenols and pigments. Concentrated fractions undergo controlled cooling and recrystallization to achieve ≥98% purity.
As a pioneer in natural plant extraction and pharmaceutical intermediates, Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) bridges the gap between raw botanical resources and global commercial applications.
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is a leading Chinese manufacturer and exporter of herbal extracts and derivatives, operating at the forefront of the industry for over 20 years. Our foundation is built upon combining advanced scientific research, scalable manufacturing processes, and international market development. We offer a comprehensive catalog including Herbal extracts, Sweeteners, Nootropics, Vegetable & Fruit Juice powders, Essential oils, and Bee Products.
TRB's consistent development and reliable customer service within the botanical extract industry culminated in being honored with the prestigious 2026 "Global Biotechnology and Life Sciences Award" - "Best Global Herbal Extract Provider 2026". This recognition highlights our strict compliance protocols, raw material traceability, and continuous active ingredient innovations.
TRB currently operates three specialized manufacturing facilities: one dedicated to herbal extract processing, one for bee product refining, and one focused on animal extract products. These plants are fully equipped with state-of-the-art analytical equipment and comply with international regulations, holding a complete portfolio of global certifications, including GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER Certificates.
Recognizing the global demand for brain health and anti-aging compounds, TRB has focused its R&D efforts on premium Nootropic formulations. These include Brain Health Herb Extracts, Anti-Aging Herb Extracts, and Longevity Herb Extracts, which continue to receive exceptional market feedback worldwide.
Procuring bulk Dihydromyricetin powder requires navigating complex variables including purity levels, physical processing (particle size), solubility barriers, and supply chain logistics. Here we address key technical solutions for international purchasing managers.
For international buyers in the United States, Europe, Japan, and South Korea, a common bottleneck is the water solubility of DHM. Natural dihydromyricetin is lipophilic and exhibits poor cold water solubility, which presents challenges for functional beverage manufacturers. To overcome this, our R&D department offers microencapsulation and cyclodextrin complexation technologies, which improve cold water dispersion and bioavailability, allowing seamless integration into ready-to-drink (RTD) cans and liquid shots.
Another major challenge in sourcing is batch-to-batch consistency. Many low-scale extraction workshops utilize basic precipitation methods that result in high levels of residual heavy metals (such as lead, arsenic, and cadmium) and pesticide residues. TRB solves this through strict control of agricultural inputs and high-efficiency purification steps. Our advanced manufacturing facility uses modern clean-in-place (CIP) loops and closed-loop evaporation systems to guarantee that every batch matches our certificate of analysis (COA) exactly.
Additionally, packaging and logistics plays a vital role in preventing active degradation. Dihydromyricetin is sensitive to light, oxygen, and high humidity, which can lead to oxidation and color shift. We package all bulk DHM powder in double-layer food-grade polyethylene bags inside fiber drums, purged with nitrogen, to guarantee a 24-month shelf life under recommended storage conditions.
Compliance is key for brand longevity. TRB provides full regulatory documentation to ensure seamless clearance and product registration across international borders.
Navigating the global regulatory landscape requires a transparent manufacturer. In the United States, dietary supplement formulations containing DHM must comply with FDA regulations under the Dietary Supplement Health and Education Act (DSHEA). TRB provides complete Technical Dossiers, including allergen statements, GMO-free declarations, BSE/TSE statements, and third-party test reports (from laboratories like SGS or Eurofins) to facilitate the NDIN (New Dietary Ingredient Notification) process.
In Europe, compliance is structured around European Food Safety Authority (EFSA) regulations. Our supply team provides complete data on residual solvents, heavy metals, PAH4, and microbiological parameters to satisfy European standards. This attention to detail has allowed TRB's products to be successfully exported to over 60 countries, building a strong reputation for reliability and quality.
We also offer localized customs clearance support for key global ports. With warehousing options and dedicated logistics partners in North America and Western Europe, we can arrange DDP (Delivered Duty Paid) shipping to minimize import complications for our commercial clients.
Find answers to the most common questions regarding product specifications, customization options, and delivery timelines for Dihydromyricetin powder.
Whether you need bulk Dihydromyricetin powder, custom formulations, or documentation to support your regulatory filing, our expert technical team is ready to assist.
Pioneer Bio-Park, No 127 North Road Xishan Bridge, Yu Hua Tai District, Nanjing, China 210012
86-25-52863298 / 86-13770771528
86-25-52867040
