1-Deoxynojirimycin (1-DNJ) is a naturally occurring polyhydroxy alkaloid (piperidine) primarily extracted from the leaves of the mulberry tree (Morus alba L.). As a structural analog of D-glucose, 1-DNJ acts as a potent, competitive inhibitor of alpha-glucosidase enzymes in the small intestine.
By mimicking glucose, 1-DNJ binds preferentially to these enzymes, significantly delaying the breakdown of complex carbohydrates into simple sugars. This biochemical pathway effectively flattens postprandial blood glucose spikes, making it one of the most sought-after natural ingredients for metabolic health, glycemic control, and weight management formulations globally.
For global nutraceutical brands and pharmaceutical formulators, sourcing high-purity, standardized 1-DNJ is critical. As leading wholesale manufacturers, we utilize advanced phytochemistry techniques to deliver consistent, bio-available 1-DNJ at scale, meeting the rigorous demands of modern clinical applications.
The global market for metabolic health supplements is undergoing a massive paradigm shift. With the rising prevalence of metabolic syndrome, pre-diabetes, and obesity worldwide, consumers and healthcare practitioners are actively seeking clinically backed, natural alternatives to synthetic pharmaceuticals. This has propelled 1-DNJ to the forefront of the functional ingredient sector.
The demand for natural alpha-glucosidase inhibitors is surging across North America, Europe, and the Asia-Pacific region, driven by clean-label trends and preventive healthcare initiatives.
Extracting 1-DNJ presents significant challenges due to its low concentration in raw mulberry leaves. Securing a reliable, large-scale supplier with dedicated cultivation bases is vital for brand stability.
Modern R&D is focusing on synergistic formulations, combining 1-DNJ with other bio-actives like Chromium, Berberine, and Nootropics to create comprehensive metabolic and cognitive health products.
Years Phytochemistry Experience
State-of-the-Art Factories
Countries Exported To
Certified Production Lines
At Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB), we have spent over two decades perfecting the extraction and isolation of 1-DNJ. Standard commercial mulberry leaf extracts often contain negligible amounts of 1-DNJ (less than 0.5%). Our proprietary extraction process allows us to offer standardized concentrations ranging from 1% to 10% HPLC, and even higher purities for specialized research applications.
1. Sourcing & Harvesting: We select premium Morus alba leaves from our controlled cultivation bases during peak bio-active accumulation phases.
2. Green Solvent Extraction: Utilizing eco-friendly, water-based extraction methods to preserve the structural integrity of the alkaloid.
3. Macroporous Resin Chromatography: Advanced column chromatography isolates 1-DNJ from other plant pigments and sugars, concentrating the active compound.
4. Membrane Ultrafiltration: Eliminates macromolecular impurities, ensuring high solubility and clarity in liquid formulations.
1-DNJ is a highly versatile active ingredient suitable for a wide array of delivery formats. Depending on your target market and local regulatory landscape, we provide tailored solutions:
Ideal for capsules, tablets, and softgels targeting blood sugar management, weight control, and metabolic health. Often paired with Gymnema Sylvestre or Cinnamon Extract.
Highly water-soluble 1-DNJ powders are perfect for ready-to-mix (RTM) drink powders, functional teas, and wellness shots aimed at post-meal glucose control.
Incorporated into meal replacement shakes, energy bars, and healthy snacks designed for low-glycemic diets and diabetic-friendly food alternatives.
In the global botanical extract industry, trust is built on rigorous compliance and transparent quality control. Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) operates three specialized manufacturing facilities equipped with advanced analytical instrumentation, including HPLC, GC-MS, and ICP-MS.
Our facilities and processes are certified under the most stringent international quality management systems:
We guarantee heavy metal limits, pesticide residue compliance, and microbiological purity that meet or exceed United States Pharmacopeia (USP) and European Pharmacopoeia (EP) standards.
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is a leading China-based manufacturer and exporter of premium herbal extracts and their derivatives, with a legacy spanning more than 20 years. As a technology-driven enterprise, we seamlessly integrate scientific research, industrial-scale production, and global sales networks.
Our diverse product portfolio includes high-quality Herbal Extracts, Natural Sweeteners, Nootropics, Vegetable & Fruit Juice Powders, Essential Oils, and Bee Products. Over the years, our commitment to innovation and quality has earned us prestigious industry recognition, culminating in the 2026 Global Biotechnology and Life Sciences Award as the "Best Global Herbal Extract Provider 2026".
With three dedicated factories specializing in herbal extraction, bee products, and animal-derived extracts, TRB is uniquely positioned to support global brands with scalable, compliant, and highly effective raw materials. Our products are exported to over 60 countries, helping to advance human health and wellness on a global scale.
As the metabolic health landscape evolves, TRB is actively investing in the next generation of phytochemistry. Our R&D roadmap focuses on three core pillars:
Developing nano-encapsulated 1-DNJ formulations to enhance cellular uptake, allowing for lower therapeutic dosages with equivalent biological efficacy.
Investigating the gut-brain axis by combining metabolic regulators like 1-DNJ with cognitive enhancers (Nootropics) for holistic mental and physical vitality.
Optimizing enzymatic and fermentation-assisted extraction methods to reduce carbon footprint and maximize active compound yields sustainably.
TRB offers standardized Mulberry Leaf Extract with 1-DNJ concentrations ranging from 1%, 2%, 5%, to 10% by HPLC. We can also customize specifications based on your specific formulation requirements.
1-DNJ is a structural analog of glucose. It competitively inhibits alpha-glucosidase enzymes in the small intestine, which slows down the digestion and absorption of carbohydrates, thereby reducing postprandial blood glucose spikes.
Our factories are fully certified with GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER, ensuring compliance with global regulatory standards for dietary supplements and food ingredients.
Our 1-DNJ powder has a shelf life of 24 months when stored in the original unopened packaging in a cool, dry place away from direct sunlight and moisture.
Yes, we provide free pre-shipment samples (typically 10-50g) along with a Certificate of Analysis (COA) for quality evaluation and laboratory verification before placing bulk orders.
Partner with a trusted global manufacturer. Contact us today for custom specifications, bulk pricing, and regulatory documentation.
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