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Tranxamic Acid (trans-4-(aminomethyl)cyclohexanecarboxylic acid) has emerged as a cornerstone compound across both pharmaceutical and cosmetic sectors globally.
Initially developed as a powerful antifibrinolytic agent to control bleeding, TXA has undergone a massive commercial expansion. Today, it is highly sought after by cosmetic formulators for its peerless ability to resolve hyperpigmentation, melasma, and UV-induced dark spots. As global demand surges, sourcing from verified, high-capacity Chinese factories has become the standard for multinational brands seeking to balance cost-efficiency with uncompromising quality.
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) stands at the forefront of this supply chain, delivering premium-grade Tranxamic Acid that meets the rigorous standards of the United States Pharmacopeia (USP), European Pharmacopoeia (EP), and British Pharmacopoeia (BP), alongside specialized ultra-pure cosmetic grades.
A technology-based pioneer combining research, development, production, and international sales for over two decades.
Nanjing Tong Rui Bio-Tech Co., Ltd. (TRB) is a leading China-based manufacturer and exporter of herbal extracts and their derivatives for more than 20 years. Our rapid development and dedicated service in the plant extract and active ingredient industry have earned us the prestigious 2026 "Global Biotechnology and Life Sciences Award" as the "Best Global Herbal Extract Provider 2026".
TRB currently operates three specialized factories:
Our manufacturing facilities hold a comprehensive suite of international certifications, including GMP, ISO, HACCP, ORGANIC, FDA, HALAL, and KOSHER, ensuring that every batch of Tranxamic Acid we export complies with the stringent regulatory frameworks of the US, EU, and Asian markets.
A deep dive into the chemical synthesis, quality parameters, and purity profiles of TRB Tranxamic Acid.
CAS Number: 1197-18-8
Molecular Formula: C8H15NO2
Molecular Weight: 157.21 g/mol
Synonyms: trans-4-(Aminomethyl)cyclohexanecarboxylic acid
Appearance: White crystalline powder, odorless with a characteristic taste.
TRB manufactures two primary grades of Tranxamic Acid:
1. Pharmaceutical Grade: Complies fully with USP, EP, and BP monographs. Assay: 99.0% - 101.0% on dried basis.
2. Cosmetic Grade: Optimized for skin-lightening formulations. Assay ≥ 99.5%, with ultra-low heavy metal profiles (Pb ≤ 2ppm, As ≤ 1ppm) and strict control over the cis-isomer impurity (≤ 0.1%).
Our factories utilize a catalytic hydrogenation process starting from p-aminomethylbenzoic acid. By optimizing temperature, pressure, and catalyst selection, we maximize the conversion to the active trans-isomer while minimizing the inactive cis-isomer. This pathway ensures high yield, low environmental impact, and consistent batch-to-batch reproducibility.
The global supply chain for Tranxamic Acid has faced significant shifts due to tightening environmental regulations in China and evolving import tariffs in Western markets. B2B procurement managers must navigate these dynamics by partnering with manufacturers who possess robust environmental compliance certificates and integrated raw material supply chains.
At TRB, we mitigate supply chain risks through:
How TRB bridges the gap between raw chemical supply and finished product success.
We supply micronized Tranxamic Acid powder that dissolves rapidly in water-based systems. Our technical team supports clients in formulating stable serums, creams, and emulsions, ensuring compatibility with other actives like Niacinamide, Kojic Acid, and Vitamin C without discoloration or crystallization.
For pharmaceutical clients, we offer API-grade Tranxamic Acid suitable for oral solids (tablets, capsules) and sterile injectables. Our cleanrooms operate under strict GMP guidelines, ensuring endotoxin levels and microbial limits are well within pharmacopoeial thresholds.
In line with TRB's focus on Nootropics, Brain Health, and Anti-Aging Herb Extracts, we research the synergistic effects of combining Tranxamic Acid with longevity compounds to address vascular health and systemic micro-inflammation.
As a forward-looking manufacturer, TRB is investing heavily in the next generation of chemical synthesis and delivery systems. Our R&D roadmap focuses on three primary pillars:
1. Green Chemistry & Biocatalysis: We are developing enzymatic pathways to synthesize Tranxamic Acid. This method aims to replace traditional heavy-metal catalysts, reducing carbon emissions by up to 40% and eliminating trace metal impurities entirely.
2. Advanced Delivery Systems: To enhance the skin penetration of cosmetic Tranxamic Acid, we are piloting liposomal and nano-emulsion carrier systems. These technologies protect the active compound from degradation and allow for lower, more effective dosing in topical applications.
3. Automated Quality Control: By integrating AI-driven HPLC (High-Performance Liquid Chromatography) and real-time process analytical technology (PAT) into our production lines, we ensure that every batch is monitored continuously, virtually eliminating batch rejection rates.
Navigating international regulatory frameworks requires more than just a high-quality product; it demands comprehensive documentation and localized support.
TRB provides full regulatory support to streamline your import process:
Expert answers to the most common technical and commercial inquiries regarding Tranxamic Acid sourcing.
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